apalutamide will reduce the level or outcome of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medications that happen to be CYP3A4 substrates may end up in decreased exposure to those remedies.Modafinil appeared to generate a f